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This release occurs in a more natural pulse-like rhythm that mimics youthful hormone patterns

doi: 10.1186/1742-2094-4-4 119 LiD.LangW.ZhouC.WuC.ZhangF.LiuQ.et al

Cell Death & Disease 6 (9): e1887

T and B lymphocytes both originate from lymphoid precursors in the bone morrow, but whereas B cells complete their maturation in the bone marrow, before entering the circulation, T cells leave the bone marrow at an immature stage and migrate to the thymus where they mature [28]