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Compared to APOE3 and APOE2, APOE4-mediated pathways of A clearance are impaired, and APOE4 exhibits a higher affinity interaction with A, potentially driving a more severe A plaque burden, 119,121,123 making it one of the strongest genetic risk factors for AD

doi:10.1186/s12970-016-0124-0

In addition, taurine has high specificity and affinity for glycine receptors (Albrecht and Schousboe, 2005) and by binding to these receptors mediates glia-neuron signaling in the hypothalamus and excitatory neurotransmission in early development of the neocortex and brain stem (El Idrissi and Trenkner, 2004

Our team has found that understanding these differences is crucial for designing effective research protocols