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10.1016/j.jare.2025.03.049 51 YangH.LvD.QuS.XuH.LiS.WangZ.et al (2024)

207.2 95.1, 97 V/21 eV, S-methyl-ET

Among them, AtGGT4 is known to have a long N-terminal sequence that determines vacuolar localization, compared to AtGGT1 and AtGGT2 that localize in the extracellular space ( Arabidopsis AtGGT4, the deduced amino acid sequences of AsGGT1 , AsGGT2 , and AsGGT3 had longer N-terminal sequences than those of Arabidopsis AtGGT1 and AtGGT2, suggesting the presence of the N-terminal signal sequences for targeting to cellular organelles in AsGGT1, AsGGT2, and AsGGT3

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A recent study reported high autophagy protein expression (AMBRA 1 and Beclin 1) in neural tissue enriched in NSCs, such as the sub-ventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus (Yazdankhah et al., in vivo and a deficiency in neuronal differentiation (Wang et al., 2013)

Future research should therefore focus on the development of stable formulations, reliable preclinical models that integrate both analgesic and regenerative endpoints, and well-designed clinical trials to validate efficacy and safety in human patients