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Oxygen and Reactive Oxygen Species in Cartilage Degradation: Friends or Foes

Recently, it has been shown that increased uptake of DA through the DAT in mice results in oxidative damage, neuronal loss and motor deficits (Masoud et al., 2015)

Early studies revealed that ATO promotes degradation of the oncogenic PML-RAR fusion proteins by directly binding to cysteines in the zinc fingers of the N-terminal RING domain of PML and PML-RAR, resulting in oligomerization, leading to enhanced SUMOylation, ubiquitination and subsequent degradation (Fig

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