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MALT1 hydrolase, located upstream of the Gln degradation pathway promoting GLS1-mediated Gln catabolism via c-Jun1, promoted epigenetic modification of H3K9Ac and H3K27Ac of the IL17A gene promoter, enhancing the chromatin accessibility of RORt (RORC), thus exacerbating IL-17A expression and ultimately causing immune peripheral blood imbalance and psoriatic lesions (79)

[DOI] [PubMed] [Google Scholar] 26.Foster K.R., Schluter J., Coyte K.Z., Rakoff-Nahoum S

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FEBS Lett (2009) 583(2):37782