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Using the K s value and divergence times, we calculated the rate of synonymous substitution per site per year to be 8 10 9 , corresponding to the WGD event, which occurred around 5 MYA (Fig

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However, different strategies, such as the timing of intervention, need to be considered during the KD

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Am J Trop Med Hygiene (2010) 6:13407

Therefore, it is possible to achieve initial concentrations that are within the therapeutic range but have concentrations fall despite continued therapy and good compliance