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governments far-reaching efforts to end HIV/AIDS include PEPFARs $85 billion investment in the global response to the disease since 2003

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2001;45:S116S24

This Nrf2 activation may work in concert with the SAHH-dependent maintenance of the transsulfuration pathway, creating a multi-layered defense system wherein DJ-1 coordinately enhances both the synthesis (via transsulfuration) and the utilization (via Nrf2-target genes like GCLM) of glutathione