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No single cause explains either condition, and the interaction between genes and environment matters more than either alone

Furthermore, single-cell profiling resolved 12 distinct cell populations, with aberrant heterotopic chondrocytes uniquely detected in OA-BML samples compared to non-OA controls and paired OA-non-BML tissues, underscoring the pathological remodeling of subchondral bone in BML progression [22]

Are Peptides Safe: Comprehensive Safety Statistics and Adverse Event Data Safety profiles for approved peptide therapeutics differ from unregulated formulations, with immunogenicity and adverse event data revealing distinct risk patterns

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That core result has held up across follow-up rodent and cell work since