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Methods: 464 patients with de novo HCC in different stages, 317 BCLC 0-A, 77 BCLC B, 65 BCLC C and 5 BCLC D were discussed in a multidisciplinary team (MTD) meeting and were treated accordingly to the decision of the team

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Berkowitz AL, Samuels MA

These findings suggest that the immunoregulatory effects of lactate are highly context-dependent, influenced by concentration, extracellular pH, and microenvironmental cues