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Secondly, the systemic NAD + metabolome is largely unexplored

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Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP (2009) The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

BMSC exosomes are internalized by damaged GCs, wherein the transferred miR-144-5p directly targets the tumor suppressor gene PTEN, which negatively regulates the PI3K/AKT signaling pathway (Huang et al

Su, Liang, et al

For instance, it is believed that epithelial cells can reprogram neighbouring stromal fibroblasts to increase the fibroblasts secretion of pyruvate and lactate, so that the epithelial cells may take up these energy-rich metabolites themselves (Pavlides et al, 2009)