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Ursodeoxycholic acid (UDCA) is a safe and effective treatment for cholestasis and can effectively treat 50% of primary biliary cholangitis patients

Microglia can change from pro-inflammatory (M1-like) to anti-inflammatory or reparative (M2-like) phenotypes, demonstrating their extraordinary adaptability

for instance, isoalloLCA enhances Treg differentiation via VDR-independent pathways involving mitochondrial ROS or NR4A1 ( Furthermore, VDR signaling pathways exhibit direct molecular crosstalk and functional competition with other key nuclear receptors sensing BAs and xenobiotics

It is difficult for the body to excrete lipid-soluble molecules, and these compounds can easily cross cell membranes, affecting cellular activities

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[48] evaluated the effects of dietary supplementation for 42 days with sodium selenite (0.35 mg/kg dry matter, DM) or selenohomolanthionine (SeHLan), an organic selenium biosynthesized by Candida utilis , at 0, 0.35, 1 or 2 mg/kg in weaned beagle puppies vaccinated for canine distemper, adenovirus type-2, parainfluenza and parvovirus (Vanguard Plus 5, Zoetis Inc., Lincoln, OR, USA) at the beginning of the feeding trial and after 21 days