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Moreover, Wnt/-catenin activation in TECs induces cellular senescence [33] and mitochondrial dysfunction characterized by mitochondrial loss, increased fragmentation, and elevated reactive oxygen species (ROS) production [34], all of which exacerbate kidney fibrosis

2023;13 doi: 10.3389/fcimb.2023.1252656

[6] [7] Ammonium ion binds more strongly than water to GS due to electrostatic forces between a cation and a negatively charged pocket

The global prevalence of MASLD has risen from 25% in 19902006 to 38% in 20162019, and its incidence is projected to increase by up to 56% by 2030 worldwide ( The G protein-coupled estrogen receptor 1 (GPER1), identified 2 decades ago as a novel estrogen receptor, distinct from classical nuclear estrogen receptors (ERs)

doi: 10.1016/j.msec.2019.109803

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