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The approach is guided by losses that try to improve the prediction confidence metrics, pLDDT and predicted alignment error (PAE), and the number of intramolecular contacts (see Methods, Cyclic Peptide Design with AfCycDesign)

Amic et al., Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine, World J

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Shahid, M., Khalid, S., Abbas, G., Shahid, N., Nadeem, M., Sabir, M.,

Mihmanli V et al

Body weight and blood glucose levels are monitored weekly