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doi: 10.1074/jbc.M209033200 45 PerrottaFScialoFMallardoMSignorielloGDAgnanoVBiancoAet al

2C), which was opposite to the effects caused by shMANF (Fig

60,61,62 RNase H-dependent ASOs, such as gapmers, bind to complementary mRNA, recruit RNase H to cleave mRNA, and thus block translation of the target gene