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Higgin J.J., et al

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Hormesis is a biphasic dose-response characterized by low-dose stimulation and high-dose inhibition, resulting in an adaptive response to stressors that enhances an organisms resilience and overall health 1

Smith DB, Johnson KS: Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Here we present the cryo-electron microscopy structure of Cdiff RNA polymerase in complex with fidaxomicin and identify a crucial fidaxomicin-binding determinant of Cdiff RNA polymerase that is absent in most gut microbiota such as Proteobacteria and Bacteroidetes