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conferred enhanced tumour targeting with a reduced T-cell exhaustion phenotype and enhanced proliferative capacity compared with the CD28 costimulatory domain, and showed potent anti-tumour activity in BCBM orthotopic xenograft models

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Hepatic clearance accounts for a significant fraction of IGF-1 catabolism

The age of the patient is an important consideration since the ratio of malignant to benign nodules is higher in youth and lower in older age

It belongs to the class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, just like sildenafil