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After first puncture, the 28-day multi-dose window starts, and refrigeration at 2-8C is consistently cited as the documented best practice in community and pharmaceutical references

However, injection requires sterile technique, comfort with needles, and scheduled clinic or home administration

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Symptmes neurologiques graves : En cas de carence avance avec des symptmes comme des picotements, des engourdissements, une instabilit de la marche ou des troubles de la mmoire, une dose rapide et leve est ncessaire pour viter des lsions nerveuses permanentes

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