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Therefore, we need to explore the resistance mechanism of sorafenib and novel treatments against HCC, such as c-Met and downstream signaling pathway inhibitors (Hu et al., 2017)

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Discussion Diagnostic approach and differential diagnoses The patient presented with signs and symptoms indicative of TMA: fatigue, delirium, acute kidney injury, elevated LDH, anemia, schistocytes on peripheral smear, and hyperbilirubinemia