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Collectively, our findings demonstrate that attenuating MDA5-dependent inflammation preserves HSC function during aging by maintaining metabolic fitness and proteostasis and provide insight into potential therapeutic strategies for mitigating hematopoietic aging

In a randomized, double-blind, placebo-controlled trial, patients with preserved small nerve fiber function as defined by QST had a statistically and clinically significant improvement in pain

Liu, H., Schreiber, S

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doi: 10.1038/ni.1698 30 ChungYChangSHMartinezGJYangXONurievaRKangHSet al

Another study demonstrated impaired heart rate responses to exercise coupled with globally impaired hemodynamic responses incompatible with patient deconditioning or prolonged inactivity [35]