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It is generally well-tolerated in topical applications and can be safely integrated into most existing skincare regimens

Park J, Jun EK, Son D, Hong W, Jang J, Yun W, et al

The enhanced inflammatory response generates a vicious loop of immune cell recruitment, tissue injury, and additional cytokine production (Vendramini-Costa and Carvalho, 2012

Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice

Bacterial as well as host catabolism of the essential amino acid tryptophan gives rise to metabolites such as indoles and kynurenines, that are sensed by the aryl hydrocarbon receptor (Ahr) 87,125

Iron overload exacerbates oxidative stress and lipid peroxidation by adversely affecting mitochondrial function and structural integrity, ultimately resulting in tissue damage