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J Cell Biol 151:601612

Insufficient thymidine can result in DNA strand breaks.30 If DHFR is being kept busy recycling BH2 back to BH4, it has reduced capacity for the Thymidylate cycle

This establishes the motivation to expand the set of actionable E3 ligases with several objectives in mind 15

Access this article Similar content being viewed by others Data availability The datasets supporting the conclusions of this article are included within the article and its supplementary information files