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The ionizable lipids in the library contained abundant ester and carbonate groups, endowing them with excellent biodegradability suitable for repeated administration

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10.1002/14651858.CD007280.pub3 52

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10.3389/fphys.2018.00180 151

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The lysosomal acid lipase LIPL-4 plays a key role, breaking down lipids, which can be bound by lipid chaperones LBP-8 and LBP-3 (Folick et al., 2015

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