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In addition, at later stages of pluripotency, -KG derived from glutamine can promote early differentiation, suggesting that the stage of cellular maturity can alter the effect of -KG 105

[12] Glucose 6-phosphate + NADP + 6-Phosphoglucono--lactone + NADPH + H + Note: this reaction produces the first molecule of NADPH in the pentose phosphate pathway

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