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The cellular repair and longevity pathway activation represents the deeper clinical rationale

Colistin-induced nephrotoxicity in mice co-injected with L-carnitine The nephroprotective effect of L-carnitine was assessed in mice treated with 20 mg/kg of colistin with or without co-injection of 30 mg/kg L-carnitine

It is transported into cells by amino acid transporters such as ASCT2 or SLC1A5 and converted into glutamate in the mitochondria via glutaminase (GLS) activity

Yet, the mechanism is basically targeted towards chromatin remodeling through deacetylation of histones that determine the compaction of chromatin which is responsible for the prevention of transcription (119)

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Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology