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Upon analysis of wt and mutant NS3 in replicon cells by SDS-PAGE and Western blot, we found that the D1476G mutant NS3 had an apparently lower molecular weight than the wt-protein (Fig

doi: 10.1016/j.bmcl.2013.08.066 105 SharmaA.SoaresC.SousaB.MartinsM.KumarV.ShahzadB.et al

This results in the generation of hybrids (daughters) having a combination of mutations which differ from the original parent mutated sequences

Effect of acute sleep deprivation on vascular function in healthy subjects

Pre-filling syringes reduces effective dose by 58% over 24 hours due to peptide adhesion to syringe walls, which compounds across multi-day protocols and undermines dosing consistency