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Stimuli such as hypoxia, oxidative stress, excitotoxicity, and/or inflammation, in addition to triggering ferroptosis, may also promote increased expression of these ABC-t

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Since a PALACE 1 study investigated that a dose of 30 mg twice a day of apremilast achieved an ACR 20 response rate of 40.0% at week 16, compared to 19.0% of the placebo group, 512 another phase III clinical trial revealed its efficacy in moderate to severe plaque psoriasis

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