analysis glutathione transferase Genome-wide of S-transferase family and their response to salinity and ammonia stresses in a freshwater shellfish Solenaia oleivora Glutathione-S-transferases and Chemotherapy Resistance of

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Puerarin can also inhibit cisplatin-induced hair cell injury by modulating apoptosis-related proteins (e.g., Bax and cleaved caspase-3) to attenuate the mitochondrial apoptotic pathway, reduce ROS accumulation and activate the Akt signaling pathway (Xu et al., 2022)

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The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail