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Even in research planning, common screening protocols exclude several groups based on the known biology of GHRH analogs and the cardiovascular signal that ended Phase 2 development

Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH