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For instance, in AD mice, mitochondrial damage increases mtDNA leakage into the cytosol, where it engages cGAS and activates STING, driving microglial secretion of type I interferons and pro-inflammatory cytokines that contribute to neuronal dysfunction [93]

the existing pre-clinical protocols use either injections or topical administration of the compound

Bile acids are synthesized from cholesterol and serum levels of 7-hydroxy-4-cholesten-3-one (C4), an intermediate product of this process, reflect the activity of bile acid synthesis (168)

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The emphasis of this page is therefore on catalog clarity, research-only designation, and practical logistics rather than any claim regarding biological application or outcome

References The Lancet (2023) Rosenstock J, et al