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Any differences in scores were resolved by discussion between the two pathologists

Stroet, M

In general, the main roles of cisplatin in the nucleus are to inhibit DNA replication and RNA transcription, arrest the cell cycle, and cause programmed cell death

Head-to-side and side-to-tail cyclizations introduce alternative ring closures by linking termini to reactive side chains, which can fine-tune conformational rigidity and surface exposure of functional groups