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GBM exploits T cell regulatory mechanisms, such as PD-L1 upregulation and TGF- signaling, to evade immune surveillance

Oral B12 supplementation requires much higher doses to achieve similar therapeutic effects

doi: 10.1021/bi00153a023

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Physicians should consider that vitamin B12 levels between 200 and 300 pg/mL (148 to 221 pmol/L) are considered borderline, suggesting a possible deficiency, and further testing with methylmalonic acid (MMA) and homocysteine may be necessary

CDDO-Me treatment increased the expression of NRF2 target genes (Fig