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Studies with GPx1 knockout mice revealed an important role of this enzyme in cardiac dysfunction (Lubos et al

For one subject, the spectrum obtained at the second post-dose time point was of insufficient quality, and was omitted from analysis

NSC48160, a Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitor, indirectly suppresses the NRF2-SLC7A11-GPX4 axis by disrupting the tricarboxylic acid (TCA) cycle, thereby promoting ferroptosis in KRAS-mutant HCC models [47]

Comprehensive molecular portraits of human breast tumours

In contrast, an overdose of APAP causes hepatotoxicity by saturating the sulfation pathway and generating NAPQI that leads to a robust reaction between NAPQI and hepatic glutathione stores, which subsequently depletes glutathione (Xie et al., 2015)

Dieser Zusammenhang ist fr die Bezeichnung Master-Antioxidans verantwortlich: Glutathion kann durch Recycling Antioxidantien reaktivieren, die der Krper sonst ber die Nahrung aufnehmen und verstoffwechseln muss