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The potentially beneficial features of IgE include its affinity for the FcR, expressed by the immune effectors responsible for ADCC and ADCP, and the low levels of normal IgE in the blood, which avoids competition with the therapeutic IgE

Since the initial exploration of IL-12 for cancer treatment in the 1990s, many of the earlier limitations related to dose-dependent toxicity and systemic inflammation have been addressed (191)

Altered regulation of iron metabolism has been shown to play a role in the pathogenesis of HCC, particularly in patients who present with NASH, hemochromatosis, or thalassemia [91, 92]

These results highlight the utility of metabolomics in elucidating mechanisms of chemically induced lung disorders and in distinguishing toxic from biocompatible polymers

These substances interfere with thyroid function, causing epigenetic changes, and can cause disease by directly damaging thyroid cells or stimulating the immune system (Andrade et al

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