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found that the valine-citrulline (Val-Cit) linker exhibits broad sensitivity to a variety of cathepsins, including cathepsin B, cathepsin K, cathepsin L, and more

Doses above 1500mg show no additional benefit in clinical trials and may cause mild gastrointestinal discomfort in some individuals

Side effects are rare but can include mild headache, lightheadedness, or temporary flushing

The BRAF mutation rate in all cancers is about 7%, but the rate varies, being about 66% in melanoma and 10%25% in CRC (155)

P53 is the most frequently mutated gene in human cancers, and the tumor suppressor protein p53 protects cells against tumorigenesis (Chen et al

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