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However, these signals can travel with the circulatory system and reach different tissues, not only confined to the lungs

MiR-33a and MiR-33b promote atherosclerosis by impairing cholesterol efflux and promoting inflammatory M1 macrophage conversion (78-80).Other microRNAs including MiR-223 and MiR-93 exhibit atheroprotective effects by increasing cholesterol efflux and conversion to the anti-inflammatory M2 macrophage phenotype (76,81-83)

These results further confirm that Cys180 is the critical residue for both caspase-3 recognition and MeCbl binding and thereby inhibition of GSDME cleavage and activation

As a benchmark, Taxol, a well-established microtubule-stabilizing compound with known efficacy in SCI models, was included as a positive control 21

Liu L, Yang X, Zhao F, Gao C, Zhang N, Bao J

Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors Bioorg