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2.5.1.1 Small molecules analysis Compounds in the samples analyzed between 2020 and 2023 were identified using a high-performance liquid chromatograph (Ultimate 3,000 system from Dionex, Thermo Fisher Scientific, Waltham, MA, United States) coupled with a high-resolution micrOTOF-QII hybrid mass spectrometer (Bruker Daltonik, Bremen, Germany)

In contrast, Cx32 has been reported the protective effects against APAP-induced liver toxicity by transporting GSH between hepatocytes, although the outcomes have been somewhat contradictory (Igarashi et al

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Postmortem studies have revealed the aggregation of -synuclein in neurons around pigment-associated lipids under oxidative conditions, and this aggregation may participate in neuronal death in PD (Halliday et al., 2005)

254 Recently promising results were reported for the use of an anti-ferroptotic compound in phase I clinical trials in amyotrophic lateral sclerosis (ALS) patients and PD patients

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