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Multiple bee stings induced multiorgan dysfunction in a 4 year old female

Am J Pathol 2001

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The utilisation of inhibitors of glutamine metabolism has been demonstrated to promote ROS formation and desensitization in PC cells, consequently resulting in altered cytokine-cytokine receptor interaction pathways, including those involving CCL5, CCR4, LTA, CXCR4, IL-6R and IL-7R, which in turn promote iron death [53]

[PUBMED Abstract] Laetsch TW, Maude SL, Rives S, et al.: Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial

However, it is contemplated herein that in some embodiments copper can be safely and effectively introduced into cells to provide healthful effects