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Azelaic acid may also possess a direct antiinflammatory effect by scavenging oxygen radicals

Extensive research involving transgenic mouse models (APP, 5FAD, SAMP8), Drosophila melanogaster , and human clinical trials has demonstrated their potential in reducing A burden, improving cognitive function, and restoring neuronal health

J Neurochem 127:552561

Specifically, hypermethylation of CpG sites at gene promoters affects specific tumor suppressor genes such as SLIT2, PTEN, OPCML, RASSF1A, p16, MLH1, E-calmodulin and APC (58)