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Interestingly, cell cycle gene expression changes immediately following hair cell degeneration coincided with a decrease in Notch and FGF signaling (Jiang et al., The molecular mechanisms of supporting cell proliferation in the chick utricle have received much attention

Although they were reported as well-tolerated, none has proceeded to Phase II studies

Cai S, Tsui YP, Tam KW, Shea GK, Chang RS, Ao Q, et al

Mistake 5: Contamination from poor technique Touching the needle tip, failing to swab the vial stopper, or reconstituting in an unclean environment all introduce bacteria

Safety isn't a binary property of a molecule

15 Limitations: Analyses using claims data are dependent on the accuracy and specificity of information provided