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Analysis of his brain revealed increased glucose metabolism in the precuneus and whole brain, high amyloid plaque burden in the cortex, and significantly low tau levels in the entorhinal cortex, posterior cingulate cortex, and precuneus

This finding suggests that NR4A3-mediated histone lactylation represents a novel metabolic-epigenetic signaling pathway involved in arterial medial calcification [235]

Clinical Significance Animal and human studies have shown that an elevated concentration of ammonia (hyperammonemia) exerts toxic effects on the central nervous system

Not with the outside world, not with some random allergen, but with itself

We report an age-dependent reduction in ratiometric measurements of free/bound GTP levels in living hippocampal neurons, which takes place mainly in mitochondria

doi: 10.3390/ijms19123851 81 WeiZFLvQXiaYYueMFShiCXiaYFet al