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Berberine Slows the Progression of Prediabetes to Diabetes in Zucker Diabetic Fatty Rats by Enhancing Intestinal Secretion of Glucagon-like Peptide-2 and Improving the Gut Microbiota

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Infusion of 0.5 mg/kg MMA III in rats resulted in venous thrombosis ( In vitro treatment with a trivalent mono methylated metabolite of arsenic MMA III (monomethylarsonous acid) up to 5 M for 4 h induces cell apoptosis, phosphatidylserine externalization, caspase activation, and procoagulant activity in human platelets (161)

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To address this clinical need, we developed an assay to screen molecular libraries to identify novel hits that can inhibit the specific binding between Munc13-4 and STX7, two modulators of endolysosomal function necessary for eTLR activation

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