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(3) ROS induces DNA oxidative damage (such as formation of 8-OHdG) and lipid peroxidation (MDA increase), triggering chondrocyte apoptosis through Bax/Bcl-2 imbalance and activation of caspase-3

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Platelet Effects The inhibition of platelet aggregation seen with ketorolac is due to dose-dependent inhibition of COX-1 in platelets leading to decreased levels of platelet thromboxane A2and an increase in bleeding time

Atorvastatin and Pravastatin Stimulate Nitric Oxide and Reactive Oxygen Species Generation, Affect Mitochondrial Network Architecture and Elevate Nicotinamide N-Methyltransferase Level in Endothelial Cells

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This clarifies a common question people ask: "is NAD a peptide?" From a structural viewpoint, NAD has two nucleotides that join through their phosphate groups