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Description

Several MR antagonists (MRAs) have been developed over the years

This synchronization aids in optimal visual pigment regeneration and the regeneration of the ocular surface during sleep, highlighting the significance of well-coordinated body rhythms

However, few clinical trials used a ligand neutralizing approach

Yin, M., Wheeler, M.D., Kono, H., Bradford, B.U., Gallucci, R.M., Luster, M.I

Even though the dosage is medical, it matters emotionally: higher doses can sometimes cause stronger sedative effects or emotional blunting, while lower doses may improve sleep with fewer mental side effects

Nevertheless, their clinical efficacy remains suboptimal, with a significant proportion of patients experiencing inadequate symptom relief and persistent functional impairment