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Clinical trial results showed modest and variable weight loss outcomes

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Whilst most patients find that initial fatigue improves within 48 weeks as the body adapts, persistent or severe tiredness warrants medical review to exclude other causes and ensure safe continuation of treatment

For example, individuals with NAFLD exhibit increased intestinal permeability and prevalence of small intestine bacterial overgrowth, and these factors are associated with the severity of hepatic steatosis 19