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Correlation heatmap analysis identified the CD4cell expression profiles of two patients as technical outliers

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Additional interactions of Met receptor with surface 51 integrin were included to be able to capture the effect of the ECM-derived mimetic peptide, AXT050, on the regulation of this pathway (Fig

GHK-Cus documented NGF stimulation appears to sit within its broader gene expression modulation signature rather than representing a direct receptor interaction, which is mechanistically coherent with the transcriptomic reactivation data showing GHK-Cu shifting aging gene expression profiles toward younger patterns (PMID: 25904764)

Caspase activation was also performed and the data totally confirmed these observations, with higher sensitivity for A549 shNRF2 and increased resistant for H23 NRF2 cell lines (Supplementary Fig