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Both protonated (left) and deprotonated (right) forms of these amino acids are depicted with average pKa values

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Increased oxidative stress in hepatitis C may be explained by chronic inflammation, and the continued generation of ROS/ RNS by NADPH oxidase 2 (NOX2) of Kupffer cells and polymorphonuclear cells in the liver [103]

Quinlan et al., 2013), complex I and complex III (Venditti et al., 2013) have been shown to be the most important sources of mitochondrial superoxide generation, although significant production of ROS in complex II has recently also been reported (Quinlan et al., 2012)

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Additionally, ELISA identified an angiogenic imbalance, evidenced by elevated sFlt-1 levels (Fig