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These components can activate the Nrf2 antioxidant pathway, upregulate the expression of antioxidant enzymes such as SOD and GSH-Px, and protect the activity of the CYP450 metabolic enzyme system

Leptin as a key regulator of the adipose organ

Unlike many antioxidants that we have to get from eating blueberries or kale, our bodies are actually little glutathione factories

IL-12 and interleukin-27 (IL-27) from the IL-12 family of cytokines are crucial for Tim-3 expression [256, 257]

Therefore, these aforementioned compounds represent promising skin-whitening agents, but those targeting TYR gene expression are not recommended for clinical use mainly for their non-specific effects through intracellular signaling cascades (73)

Bruce D