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This mechanism not only reshapes the immunosuppressive state of the tumor microenvironment but also provides key targets for breaking immune tolerance and improving the efficacy of immunotherapy

Screen-detected HCC was defined as abnormal surveillance-intent abdominal imaging or alpha-fetoprotein within 6 months before diagnosis

Borg, W., Shackleton, C

Curcumin upregulates PGC-1 via AMPK signaling, subsequently enhancing PPAR activity and Superoxide Dismutase-2 (SOD-2) transcription/activity, thereby suppressing 1(I) collagen expression in cultured HSCs (Zhai et al., 2015)

Setria Glutathione has been shown to decrease oxidative stress and significantly boost glutathione levels

However, rutin is capable of creating adducts with histidine residues in the active site of tyrosinase, which leads to tyrosinase inhibition and stops the production of melanin [74]