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Ferroptosis is triggered by inactivation of cellular glutathione (GSH)-dependent antioxidant defenses, leading to the accumulation of toxic lipid ROS (L-ROS) [5, 6] (Fig

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Initiation and Fatty Streak Phase of Atherosclerotic Lesions The endothelial lining of arteries responds to mechanical and molecular stimuli to regulate tone, (4) hemostasis, (5) and inflammation (6) throughout the circulation