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Once neuroplasticity is established (after the induction phase), less frequent maintenance dosing may sustain effects, but initial protocols should follow daily administration schedules to maximize therapeutic outcomes

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Once released into the bloodstream, IGF-1 travels to tissues and organs where it helps regulate growth, cellular repair, metabolism, muscle maintenance, and bone remodeling

Elevated expression of IGF-IR in BCR/ABL + cells may promote the development and self-renewal of chronic myeloid leukemia, while downregulation of IGF-IR in BCR/ABL + cells leads to acute lymphoblastic leukemia (ALL) [14]

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